Outcome of septic shock in the neonatal period
Septic shock in the neonatal period has a very poor outcome.
Study n = 48
The 28-day mortality was 40%. Adverse outcome at 18 months of corrected age was observed 52% cases (death = 19, severe sequelae = 5). 28% of the infants were alive and had a normal examination at 18 months.
Significant predictors (multivariate analysis) of 28-day mortality and of adverse outcome at 18 months of corrected age were:
- Weight (kg) at the onset of sepsis
- Gram-negative infection
Conclusions: Data underscore the extreme vulnerability of very low birth weight infants to septic shock, particularly to Gram-negative species.
Reference:
Outcome and prognostic factors in neonates with septic shock - Pediatric Critical Care Medicine. 9(2):186-191, March 2008
